Adolescent arterial stiffness — a new risk factor for hypertension and insulin resistance — ScienceDaily

Emerging evidence suggests that arterial stiffness may be a new risk factor to target in the prevention and treatment of vascular and metabolic diseases from an early age, concludes a review of studies published in the Journal of Hypertension.

The prevalence of hypertension and obesity is increasing worldwide, despite targeted efforts to promote weight loss, increase physical activity and reduce sedentary time in the general population. This global challenge informed a recent scientific statement from the American Heart Association on continued research into obesity and hypertension to lessen this health burden.

In middle-aged and elderly adults, arterial stiffness has been established as a strong predictor of cardiovascular events and all-cause mortality. Therefore, a few clinical trials in adults are currently underway looking at the likelihood of reversing arterial stiffness. However, in children, adolescents, and young adults, arterial stiffness has been relegated to an intermediate marker of cardiovascular disease and death that occurs in middle age, not thanks to limited longitudinal data and repeated measures of arterial stiffness in a fairly healthy young population. .

Moreover, the clinical utility of arterial stiffness as a risk factor for early vascular and metabolic disease is largely unrecognized in pediatrics. In this review, recent prospective evidence in a large adolescent population and a middle-aged population that underscores the value of arterial stiffness as a novel risk factor for hypertension, overweight/obesity, resistance to insulin, dyslipidemia and type 2 diabetes mellitus were summarized. We often wonder what are the risk factors for higher blood stiffness in adolescents? Maternal smoking habits, adolescent smoking habits in early life, high salt intake, genetic inheritance, obesity, and increased blood from childhood are known to contribute to stiffness. higher blood pressure in adolescence.

“Arterial stiffness in adolescence appears to be a subtle, stealthy, but potent risk factor for high blood pressure and metabolic alteration, setting off a cascade of biological events ultimately leading to the formation of diseases such as type 1 diabetes mellitus. 2 and premature organ damage, so it is timely for clinicians, pediatricians, public health experts and policy makers to focus on ways to treat, reduce and possibly reverse arterial stiffness, particularly at from adolescence. Intervention for arterial stiffness in adolescence may reduce the incidence of hypertension and metabolic diseases later in life, but more studies are needed,” says Andrew Agbaje, physician and clinical epidemiologist at the University of Eastern Finland.

This study was supported by research grants from the Jenny and Antti Wihuri Foundation, Finnish Cultural Foundation Central Fund, Finnish Cultural Foundation North Savo Regional Fund, Orion sr Research Foundation, Aarne Foundation Koskelo, the Antti and Tyyne Soininen Foundation, the Paulo Foundation, the Yrjö Jahnsson Foundation, the Paavo Nurmi Foundation and the Finnish Foundation for Cardiovascular Research.

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Material provided by University of Eastern Finland. Note: Content may be edited for style and length.

Irene B. Bowles